Effects of pituitary adenylate cyclase activating polypeptide (PACAP) in corneal epithelial regeneration and signal transduction in rats

The Neuroprotective Effects of Pituitary Adenylate-cyclase Activating Polypeptide (pacap) in Focal Cerebral Ischemia

Pituitary adenylate cyclase activating polypeptide and migraine

Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headach...

PS16. Genetic variation and expression diversity of pituitary adenylate cyclase-activating polypeptide (PACAP) gene in mouse

Pituitary adenylate cyclase-activating polypeptide (PACAP) gene codes a peptide hormone that is important for regulation of emotions such as anxiety and fear. However, genetic influence on the functions remains poorly understood. Here we describe genetic variation and expression diversity of the PACAP gene to identify functional differences that influence and contribute to phenotypic diversity ...

Rapid desensitization of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) in chick cerebral cortex.

Pituitary adenylate cyclase-activating polypeptide (PACAP38) potently stimulates cyclic AMP formation in slices of chick cerebral cortex. One- to fifteen-minute pretreatment of slices with 30 nM PACAP38 led to a time-dependent attenuation (when compared with values observed in the control tissue) of the cyclic AMP response produced by subsequent re-stimulation with 1 microM PACAP38. Concentrati...

Pituitary adenylate cyclase-activating polypeptide (PACAP) in zebrafish models of nephrotic syndrome

Pituitary adenylate cyclase-activating polypeptide (PACAP) is an inhibitor of megakaryopoiesis and platelet function. Recently, PACAP deficiency was observed in children with nephrotic syndrome (NS), associated with increased platelet count and aggregability and increased risk of thrombosis. To further study PACAP deficiency in NS, we used transgenic Tg(cd41:EGFP) zebrafish with GFP-labeled thr...